Supply 5-Aminosalicylic Acid /Mesalazine CAS 89-57-6

• CAS No.: 89-57-6
• Formule: c7h7no3
• EINECS: 201-919-1
• Type: farmaceutisch
• Verschijning: Poeder
• Kwaliteit: naar boven
• Model NR.: py0803
• Colour: Wit
• standaard: usp bp ep
• moq: 1 kg
• pakket: doos
• verzending: fedex
• Transportpakket: 25kg/Drum
• Specificatie: 99%
• Handelsmerk: Puya
• Oorsprong: China
• Productiecapaciteit: 10ton/Year

Beschrijving

5-Aminosalicylic Acid /Mesalazine CAS 89-57-6
Mesalazine is the active ingredient of SASP in the treatment of ulcerative colitis.It has a significant inhibitory effect on the inflammation of intestinal wall.Mesalazine can inhibit the synthesis of prostaglandins that cause inflammation and the formation of leukotriene, which is an inflammatory mediator, and thus has a significant inhibitory effect on intestinal mucosal inflammation.Mesalachine can inhibit the synthesis of prostaglandin in a dose-dependent manner and reduce the release of PGE2 in human colonic mucosa.

Name	5-Aminosalicylic acid
CAS No	89-57-6
MF	C7H7NO3
Purity	99%
Appearance	white powder

Specification

Items	Specification	Results
Appearance	Almost white or light gray or light pink powder or crystals	Complies
Identification	IR/UV/TLC	Complies
A Single Unknown Impurities	≤0.05%	0.02%
Total impurities	≤0.5%	0.09%
Chloride	≤0.1%	Complies
Sulfate	≤200ppm	Complies
Heavy metals	≤10ppm	Complies
Loss on drying	≤0.5%	0.07%
Residue on ignition	≤0.2%	0.05%
Assay	98.5%-101.0%	99.91%

Mesalazine is an anti-inflammatory agent, structurally related to the salicylates, which is active in inflammatory bowel disease. It is considered to be the active moiety of sulphasalazine. A study of the therapeutic properties of sulfasalazine and its constituents[mesalazine (5-amino salicylic acid, 5-ASA) and sulfapyridine] indicated that mesalazine is the therapeutically active component, while sulfapyridine acts as an inert carrier molecule to facilitate delivery to the colon. This discovery, coupled with the implication of sulfapyridine in most of the adverse events associated with sulfasalazine treatment, led to the development of Mesalazine as a pure therapeutic entity.

Function
Uses The active metabolite of Sulfasalazine (S699084). Anti-inflammatory (gastrointestinal).
Uses anesthetic (local)
Uses peroxidase substrate
Uses For the treatment of active ulcerative proctitis.
Uses In manufacture of light-sensitive paper, azo and sulfur dyes.